Rostafuroxin (PST-2238)
(3β,5β,14β)-21,23-Epoxy-24-Norchola-20,22-diene-3,14,17-triol
CAS: 156722-18-8
Molecular Formula: C23H34O4
Rostafuroxin (PST-2238) - Names and Identifiers
Rostafuroxin (PST-2238) - Physico-chemical Properties
| Molecular Formula | C23H34O4 |
| Molar Mass | 374.51 |
| Density | 1.226±0.06 g/cm3(Predicted) |
| Boling Point | 451.3±45.0 °C(Predicted) |
| pKa | 14.02±0.70(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| In vitro study | Rostafuroxin (PST 2238) competitively inhibits Ouabain (HY-B0542) binding and signaling. Rostafuroxin antagonizes the molecularand functional effects of Ouabain by reversing the ouabain-induced, Src-dependent Na + ,K + -ATPase phosphorylation and activation. Rostafuroxin (0.125-128 μM; for 24 h post treatment) has less than 20% reduction in cell viability in A549 cells and HSAEC. Rostafuroxin inhibits the expression of RSV-GFP in HSAEC (IC 50 =1.8 μM) and A549 cells (IC 50 =14.8 μM). Rostafuroxin displaced [ 3 H]Ouabain from the dog kidney Na + ,K + -ATPase receptor (IC50=1.5 nM), is devoid of cardiac inotropic activity in isolated guinea pig atria, and shows no affinity up to 10 -4 M with general (R1, R2, a1, a2, A1, A2, M1, M2, H1, H2, 5-HT1, 5-HT2, Ca2+ channels, TXA2/PGH2, PAF, GABAA, GABAB, DA-NE-5-HT uptake, glutammate,glycine, benzodiazepine) and hormonal (estrogenic, progestinic, androgenic, mineralcorticoid) receptors. |
| In vivo study | Rostafuroxin (PST 2238; 1 mg/kg/day; gavage; for 3 weeks) decreases SBP and improves acetylcholine-induced relaxation. Animal Model: Male 7-week-old Wistar rats Dosage: 1 mg/kg Administration: Gavage; daily; for 3 weeks Result: Decreased SBP, improved acetylcholine-induced relaxation via enhanced nitric oxide synthesis and bioavailability, decreased superoxide anion generation from NAD(P)H oxidase and cyclooxygenase-2 and reduced cytoplasmic tyrosine kinase Src phosphorylation. |
Rostafuroxin (PST-2238) - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.67 ml | 13.351 ml | 26.702 ml |
| 5 mM | 0.534 ml | 2.67 ml | 5.34 ml |
| 10 mM | 0.267 ml | 1.335 ml | 2.67 ml |
| 5 mM | 0.053 ml | 0.267 ml | 0.534 ml |
Last Update：2024-01-02 23:10:35
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View History
Rostafuroxin (PST-2238)
Reactive Navy Blue Ker
C8~C10双烷基叔胺
甲基3-(4-羟基苯基)丙酸甲酯
N-[(2,4-difluorophenyl)carbamothioyl]thiadiazole-4-carboxamide
3-TERT-BUTOXYCARBONYLAMINO-3-(3,4-DICHLORO-PHENYL)-PROPIONIC ACID
SOYASAPONIN I(SH)
OLEYL STEARATE
4-(4-氨基苯氧基)丁酸
(3R)-六氢-3-[(苯基甲基)氨基]-2H-氮杂卓-2-酮
Reactive Navy Blue Ker
C8~C10双烷基叔胺
甲基3-(4-羟基苯基)丙酸甲酯
N-[(2,4-difluorophenyl)carbamothioyl]thiadiazole-4-carboxamide
3-TERT-BUTOXYCARBONYLAMINO-3-(3,4-DICHLORO-PHENYL)-PROPIONIC ACID
SOYASAPONIN I(SH)
OLEYL STEARATE
4-(4-氨基苯氧基)丁酸
(3R)-六氢-3-[(苯基甲基)氨基]-2H-氮杂卓-2-酮